Detection of tumour lymphovascular space invasion using dual cytokeratin and CD31 immunohistochemistry

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Detection of tumour lymphovascular space invasion using dual cytokeratin and CD31 immunohistochemistry.

BACKGROUND Lymphovascular space invasion (LVSI) is an important step in the complex process of tumour metastasis. Various methods have been used in the past to improve the histological detection of LVSI. AIMS To develop a sensitive immunohistochemical method for the detection of LVSI. METHODS Paraffin wax blocks from 108 patients who had undergone hysterectomy for stage I endometrial cancer...

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Prognostic Significance of Lymphovascular Space Invasion in Epithelial Ovarian Cancer

OBJECT To assess the effects of lymphovascular space invasion (LVSI) on cancer recurrence and survival in patients with primary epithelial ovarian cancer. METHODS A retrospective study was conducted of patients with stage I-IV primary epithelial ovarian cancer who underwent cytoreductive surgery. LVSI is defined as the presence of tumor cells within an endothelium-lined space, and the patient...

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Lymphovascular Space Invasion in Robotic Surgery for Endometrial Cancer

BACKGROUND Minimally invasive surgery has become a standard treatment for endometrial cancer and offers significant benefits over abdominal approaches. There are discrepant data regarding lymphovascular space invasion (LVSI) and positive peritoneal cytology with the use of a uterine manipulator, with previous small-scale studies demonstrating an increased incidence of these prognostically impor...

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Erratum: Correction of Acknowledgments. ERG Immunohistochemistry as an Endothelial Marker for Assessing Lymphovascular Invasion

BACKGROUND ERG, a member of the ETS family of transcription factors, is a highly specific endothelial marker. We investigated whether the use of ERG immunostaining can help pathologists detect lymphovascular invasion (LVI) and decrease interobserver variability in LVI diagnosis. METHODS Fifteen cases of surgically resected colorectal cancers with hepatic metastasis were selected and the most ...

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Objective The aim of this work is to show the importance of the depth of myometrium invasion, tumour size and lymphovascular invasion as prognostic factors in dissemination of lymphatic nodes at endometrial carcinoma (CE). Materials and methods In the period from 2010 to 2015 at the University Clinic for Gynecology and Obstetrics in Banja Luka, 221 endometrial cancer surgeries were done (lapa...

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ژورنال

عنوان ژورنال: Journal of Clinical Pathology

سال: 2003

ISSN: 0021-9746

DOI: 10.1136/jcp.56.10.786